Endocrine Abstracts

Introduction: Loss of anosmin-1 function underlies the pathogenesis of X-linked Kallmann's syndrome (X-KS), a disorder characterized by anosmia (loss of smell) and hypogonadotrophic hypogonadism, due to olfactory bulb (OB) dysgenesis and failed migration of gonadotrophin releasing hormone (GnRH) neurons. Additional phenotypic features include bimanual synkinesis and unilateral renal agenesis. Anosmin-1 contains a whey acidic protein-like (WAP) domain and four contiguous fibron...

Objective: We retrospectively analyzed patients with type 1 diabetes onset, attended during the years 2005 and 2006 on the specific query of type 1 DM debut of a tertiary hospital, with initial treatment assessment, at 1 and 5 years evolution.Results: Patients were treated for newly diagnosed DM 1, 25 patients (72% male, 28% female) mean age 23.2 years (14–36), mean BMI: 23.18 (18–33.8%).The clinical presentation included: 88.24% presented with...

Aims (objectives): Energy intake and expenditure are regulated by different signals. One of the molecules implicated is islet amyloid polypeptide (IAPP or amylin), one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a peptide that inhibits insulin and glucagon secretion, and can also act through the brain decreasing food intake and inhibiting gastric emptying. In this study, we investigated the potential effects of the chronic cent...

Methods: Restrospective descriptive study of patients who underwent ETPS for pituitary adenoma removal performed by the same surgical team in Virgen del Rocio Hospital of Seville from January 2014 to January 2019.Results: 174 patients had a pituitary adenoma (44 GH, 36 ACTH, 94 Non functioning). 54.02% were female. In acromegaly, 39 (88.63%) patients were operated by ETPS as initial approach. 20 (51.28%) patients had cavernous sinus invation. At outcome ...

Objectives: MODY diabetes is the most common form of monogenic diabetes, encompassing a heterogeneous group of disorders whose primary defect results from mutations in one of at least seven genes recognized, associated with a primary defect in insulin secretion. It has early onset and autosomal dominant inheritance.Our objective was to evaluate the results of monogenic diabetes clinic of the Endocrinology and Nutrition Department during 2008–2012.</...

It is important to know the prevalence of common diseases in every country in order to guide us to take decisions regarding public health benefits in screening, in Mexico we do not have information regarding thyroid abnormalities.Methods: We designed a cross-sectional study in the city of Queretaro (Mexico) in order to know the prevalence of altered thyroid function tests in our population, since we do not have any previous study. We calculated the sampl...